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目的分析趋化因子受体CXCR4在乳腺癌中的表达及其与乳腺癌临床病理特征的关系,探讨CXCR4在乳腺癌发病中的作用。方法应用免疫组织化学方法检测46例乳腺癌组织、30例乳腺癌旁组织和30例正常乳腺组织中CXCR4的表达,分析其不同表达与患者年龄、肿瘤大小、雌激素受体(ER)、孕激素受体(PR)、TNM分期、病理分级和淋巴结转移等临床特征的关系。结果46例乳腺癌组织中CXCR4的表达率为61%,显著高于正常乳腺组织和乳腺癌旁组织,差异有高度统计学意义(P<0.01)。乳腺癌组织中CXCR4的高表达与TNM分期、病理分级和淋巴结转移相关(均P<0.05)。结论CXCR4在乳腺癌中有较高的表达率,其可能在协同促进乳腺癌的侵袭转移中起重要作用。
Objective To analyze the expression of chemokine receptor CXCR4 in breast cancer and its relationship with the clinicopathological features of breast cancer, and to explore the role of CXCR4 in the pathogenesis of breast cancer. Methods The expression of CXCR4 in 46 cases of breast cancer tissue, 30 cases of breast cancer adjacent tissues and 30 cases of normal breast tissues were detected by immunohistochemical method. The expressions of CXCR4 in different tissues, including age, tumor size, estrogen receptor (ER) Hormone receptor (PR), TNM staging, pathological grading and lymph node metastasis and other clinical features. Results The expression rate of CXCR4 in 46 cases of breast cancer tissues was 61%, which was significantly higher than that in normal breast tissues and paracancerous tissues (P <0.01). The high expression of CXCR4 in breast cancer was correlated with TNM staging, pathological grade and lymph node metastasis (all P <0.05). Conclusion CXCR4 has a high expression rate in breast cancer, which may play an important role in promoting the invasion and metastasis of breast cancer.