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目的探讨NT-proBNP在严重创伤失血性休克患者早期液体复苏中的指导意义,为临床实践提供参考。方法收住急诊ICU的严重创伤失血性休克患者150例,随机分为NT-proBNP指导组与对照组(CVP组),采用相同液体复苏方法 ,比较两组液体复苏6 h时EGDT复苏指标的达标率及复苏6 h与24 h对血流动力学指标的影响。结果复苏6 h,NT组达标率为85.3%(64/75),对照组达标率为88.0%(66/75)。两组比较差异无统计学意义(P>0.05)。患者复苏6 h、24 h后,血流动力学指标CI、CO、GEF、ITBI、GEDI两组比较差异无统计学意义(P>0.05);EVLWI两组比较,差异有统计学意义(P<0.05)。结论 NT-proBNP是一个很好的反映心脏容量负荷的预测指标,可以用于指导创伤失血性休克的早期液体复苏治疗。
Objective To investigate the guiding significance of NT-proBNP in early liquid resuscitation in patients with severe traumatic hemorrhagic shock and provide reference for clinical practice. Methods One hundred and fifty patients with severe traumatic hemorrhagic shock admitted to the emergency department of ICU were randomly divided into three groups: control group and NT-proBNP group (CVP group). The same liquid resuscitation method was used to compare the compliance of EGDT resuscitation index Effect of 6 h and 24 h resuscitation on hemodynamic parameters. Results The recovery rate was 85.3% (64/75) in the NT group and 88.0% (66/75) in the control group at 6 hours after resuscitation. There was no significant difference between the two groups (P> 0.05). There was no significant difference in hemodynamic parameters CI, CO, GEF, ITBI and GEDI between 6 h and 24 h after resuscitation (P> 0.05). There was significant difference between the two groups in EVLWI (P < 0.05). Conclusion NT-proBNP is a good predictor of cardiac capacity load and can be used to guide the early liquid resuscitation of traumatic hemorrhagic shock.