芳香或脂肪羧酸在DMSO中先在室温由羰基二咪唑和4-二甲胺基吡啶催化与O-三甲基硅基羟胺反应得到异羟肟酸,再加碳酸钾并升温90℃由Lossen重排得到伯胺。21例收率10%~85%。羧酸α-位位阻较大时收率降低,三苯基乙酸不反应,α-位有手性时可能消旋, Aromatic or aliphatic carboxylic acids were first reacted with O-trimethylsilylhydroxylamine in DMSO at room temperature by carbonyldiimidazole and 4-dimethylaminopyridine to give the hydroxamic acid followed by addition of potassium carbonate and warming at 90 ° C by Lossen Rearrange to get primary amine. 21 cases of 10% to 85% yield. When the steric hindrance of the α-position of the carboxylic acid is large, the yield decreases, the triphenylacetic acid does not react, the racemization may occur when the α-position is chiral,