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目的 观察肝硬化患者胆囊胆汁成份改变,分析与肝硬变胆石多发的关系。 方法 术中抽取24例肝硬化患者胆囊胆汁,测定脂类、胆红素及金属元素钾、钠、钙、镁、铜、铁、锌。 结果 肝硬化胆囊胆汁中未结合胆红素水平明显增高,总胆汁酸、胆固醇、磷脂浓度和胆汁粘度明显下降。金属元素中钾、镁、铜、锌水平下降,铁含量显著升高。 结论 肝硬化胆囊胆汁具有明显成色素性结石趋势。因此,肝硬化胆汁成分改变是易于形成结石的基础。
Objective To observe the change of gallbladder biliary composition in patients with cirrhosis and analyze the relationship with gallstone in cirrhosis. Methods Twenty-four patients with gallbladder gallbladder were enrolled in this study. Lipids, bilirubin and metallic elements such as potassium, sodium, calcium, magnesium, copper, iron and zinc were determined. Results The level of unconjugated bilirubin in gallbladder bile of cirrhosis increased significantly, and the total bile acid, cholesterol, phospholipid concentration and bile viscosity decreased obviously. The content of potassium, magnesium, copper and zinc in the metal elements decreased, while the iron content increased significantly. Conclusions The gallbladder bile of cirrhosis has obvious tendency of pigmentation. Therefore, changes in biliary composition of cirrhosis is the basis for easy formation of stones.