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原发性胆汁性肝硬化(PBC)是以有肝内胆管慢性非化脓性病变和很多血清学异常(如高丙球蛋白血症、多种抗体、补体激活和循环免疫复合物存在)为特征的缓慢进行的疾病。用间接免疫荧光或补体结合试验,在84～96%PBC病人血清中可检得抗线粒体抗体(AMA)。作者收集PBC 2例、全身性红斑狼疮(SLE)40例、类风湿性关节炎(RA)15例、慢性活动性肝炎8例、慢性酒精性肝炎7例和正常成人15例的血清标本,采用鼠肝线粒体进行试验。
Primary biliary cirrhosis (PBC) is characterized by chronic non-suppurative intrahepatic bile duct lesions and many serological abnormalities (such as hypergammaglobulinemia, multiple antibodies, complement activation, and circulating immune complexes) The disease carried out. Using indirect immunofluorescence or complement fixation assay, anti-mitochondrial antibodies (AMA) were detected in sera from 84 to 96% of PBC patients. We collected 2 cases of PBC, 40 cases of systemic lupus erythematosus (SLE), 15 cases of rheumatoid arthritis (RA), 8 cases of chronic active hepatitis, 7 cases of chronic alcoholic hepatitis and 15 cases of normal adult serum samples Rat liver mitochondria were tested.