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目的探讨胃癌及癌前疾病中热休克蛋白27(heat shock protein 27,HSP27)的表达及幽门螺杆菌(Hp)感染的情况,并研究两者之间的关系。方法选取经病理证实的慢性浅表性胃炎、胃溃疡、慢性萎缩性胃炎和胃癌4种不同胃黏膜病变的标本140例,用免疫组化法检测标本中HSP27的表达及Hp感染情况,并分析HSP27的表达与Hp关系。结果在慢性浅表性胃炎、胃溃疡、慢性萎缩性胃炎和胃癌组织中,HSP27的表达率(44.0%、60.0%、74.3%、94.0%)和Hp感染率(24.0%、43.3%、51.4%、72.0%)依次逐渐增加。胃癌中Hp阳性组HSP27的表达率高于阴性组(100.0%vs78.6%,P<0.05),HSP27的表达率与Hp感染之间呈正相关(r=0.526,P<0.05)。结论HSP27和Hp与肿瘤的发生密切相关,检测HSP27及Hp可为胃癌诊断、预后判断和治疗指导提供理论依据。
Objective To investigate the expression of heat shock protein 27 (HSP27) and Helicobacter pylori (Hp) infection in gastric cancer and precancerous lesions and to study the relationship between the two. Methods 140 pathologically confirmed chronic superficial gastritis, gastric ulcer, chronic atrophic gastritis and gastric cancer specimens of four different gastric mucosal lesions were selected 140 cases, the expression of HSP27 and Hp infection were detected by immunohistochemistry Relationship between HSP27 expression and Hp. Results The positive rates of HSP27 expression in chronic superficial gastritis, gastric ulcer, chronic atrophic gastritis and gastric cancer tissues were 44.0%, 60.0%, 74.3%, 94.0% and 24.0%, 43.3%, 51.4% , 72.0%) in turn gradually increased. The positive rate of HSP27 in Hp positive group was significantly higher than that in negative group (100.0% vs 78.6%, P <0.05). The positive rate of HSP27 expression was positively correlated with Hp infection (r = 0.526, P <0.05). Conclusions HSP27 and Hp are closely related to tumorigenesis. Detection of HSP27 and Hp may provide a theoretical basis for the diagnosis, prognosis and treatment of gastric cancer.