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目的:观察齿痛消炎灵颗粒对牙周炎的治疗作用及对临床症状改善的效果。方法:将120例慢性牙周炎急性发作的患者随机分为2组各60例。2组均予口腔科常规治疗,在此基础上对照组予甲硝唑片配合阿莫西林克拉维酸钾分散片口服治疗,中药组则予齿痛消炎灵颗粒进行治疗,2组疗程均为7天。疗程结束前后均测算患者牙菌斑指数(PLI)、牙龈指数(GI)、龈沟出血指数(SBI)和牙周袋深度(PD),观察临床症状改善情况以评价疗效,并随访患者治疗期间不良反应发生情况。结果:总有效率中药组稍优于对照组,但2组比较,差异无统计学意义(P>0.05);治疗后,2组患者PLI、GI、SBI及PD均较治疗前下降,差异均有统计学意义(P<0.05,P<0.01);中药组PLI、GI较对照组下降幅度更大,差异均有统计学意义(P<0.05)。不良反应发生率对照组15.0%,中药组3.3%,2组不良反应发生率比较,差异有统计学意义(P<0.01)。结论:齿痛消炎灵颗粒治疗牙周炎能有效改善患者临床症状,治疗效果与抗生素联合治疗相当,能减少PLI、GI、SBI及PD,且不良反应较单纯西药治疗少。
Objective: To observe the therapeutic effect of Toutong Xiaoyanling granule on periodontitis and its effect on clinical symptom improvement. Methods: 120 patients with acute episodes of chronic periodontitis were randomly divided into two groups of 60 cases. 2 groups were given routine treatment of dentistry, on the basis of the control group were treated with metronidazole tablets combined with amoxicillin and clavulanate dispersible tablets oral treatment, the Chinese medicine group was treated with Tacheng Xiaoyanling particles were treated two groups were 7 days. The plaque index (PLI), gingival index (GI), sulci bleeding index (SBI) and periodontal pocket depth (PD) were measured before and after the treatment. The improvement of clinical symptoms were observed to evaluate the efficacy and follow-up of patients during treatment Adverse reactions occurred. Results: The total effective rate of Chinese medicine group was slightly better than that of control group, but there was no significant difference between the two groups (P> 0.05). After treatment, the PLI, GI, SBI and PD decreased (P <0.05, P <0.01). The decrease of PLI and GI in Chinese medicine group was more significant than that in control group, with statistical significance (P <0.05). The incidence of adverse reactions was 15.0% in the control group and 3.3% in the traditional Chinese medicine group, with significant differences in the incidence of adverse reactions between the two groups (P <0.01). Conclusion: Tutong Xiaoyanling granule can effectively improve the clinical symptoms of patients with periodontitis. The treatment effect is comparable with antibiotic combination therapy, and can reduce PLI, GI, SBI and PD, and the adverse reaction is less than western medicine alone.