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目的 :综合分析盐酸戊乙奎醚注射液联合阿托品治疗急性有机磷中毒的临床效果。方法 :选取在我院2015年6月-2016年7月收治的急性有机磷中毒患者临床资料66例作为研究对象,按照入院顺序随机分为实验组与对照组,每组均为33例。对照组应用阿托品治疗方法,实验组应用盐酸戊乙奎醚注射液联合阿托品治疗方法。采用SPSS20.0统计学软件进行统计学分析两组患者的中毒症状维持时间、平均住院时间、不良反应发生率以及ChE(胆碱酯酶)恢复时间等。结果 :实验组中毒症状维持时间、平均住院时间以及ChE恢复时间显著低于对照组(P<0.05);实验组不良反应发生率为6.06%(2/33),对照组不良反应发生率为21.21%(7/33),实验组不良反应发生率远远低于对照组(P<0.05)。结论 :盐酸戊乙奎醚注射液联合阿托品治疗急性有机磷中毒的临床效果显著。
Objective: To analyze the clinical effect of penehyclidine hydrochloride injection combined with atropine in the treatment of acute organophosphate poisoning. Methods: Sixty-six patients with acute organophosphate poisoning who were admitted to our hospital from June 2015 to July 2016 were selected as study subjects and randomly divided into experimental group and control group according to admission order, with 33 cases in each group. The control group was treated with atropine, and the experimental group was given penehyclidine hydrochloride injection combined with atropine treatment. Using SPSS 20.0 statistical software for statistical analysis of two groups of patients with symptoms of poisoning to maintain time, the average length of stay, the incidence of adverse reactions and ChE (cholinesterase) recovery time. Results: The maintenance time of poisoning symptoms, average length of stay, and ChE recovery time in the experimental group were significantly lower than those in the control group (P <0.05). The incidence of adverse reactions in the experimental group was 6.06% (2/33) and that in the control group was 21.21 % (7/33). The incidence of adverse reactions in the experimental group was much lower than that in the control group (P <0.05). Conclusion: Penehyclidine hydrochloride injection combined with atropine in the treatment of acute organophosphate poisoning has a significant clinical effect.