从1921年到几年前,已有数百万人口服卡介苗(BCG),试图诱发对结核病的防御作用。近年来口服BCG作为一种非特异性免疫刺激剂用于人体癌症的免疫治疗。然而BCG对消化过程的敏感性、吸收的菌量及其在宿主体内的转归,尚未明了。作者用pH 1.92的人造胃液、通过胃十二指肠内窥镜获取的人十二指肠液(pH6.7)和pH 7.4的磷 From 1921 to a few years ago, millions of people had been given BCG in an attempt to induce a defensive effect on TB. In recent years, oral BCG as a non-specific immunostimulant used in human cancer immunotherapy. However, the sensitivity of the BCG to the digestive process, the amount of bacteria absorbed and its consequences in the host are not known. The authors used artificial gastric fluid having a pH of 1.92, human duodenal fluid (pH 6.7) obtained by gastroduodenal endoscopy and phosphorus