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二苯丙氨酸二肽(L-Phe-L-Phe,FF)是引起阿尔兹海默症的A?-多肽成纤维的关键识别序列,具有优异的自组装性能,是制备生物功能性纳米材料的重要组装基元.迄今为止,研究者已制备出多种FF基微纳米结构,但是如何有效地控制自组装材料的形状和尺寸一直都是研究的关键和热点.近年来,本课题组通过改变组装条件以及引入外源小分子等方法来调控FF基肽分子的组装,成功实现了对肽基组装材料的形状、结构和功能的调控.这些研究不仅丰富了FF基肽分子的组装结构,同时也为其他肽基纳米材料的制备和生物功能材料的开发提供了新的策略和重要的实验依据.
Diphenylalanine dipeptide (L-Phe-L-Phe, FF) is the key recognition sequence of A? -polypeptide fibrils that cause Alzheimer’s disease and has excellent self-assembly properties, However, how to effectively control the shape and size of self-assembled materials has always been the key and hot point in the research.In recent years, our group By changing the assembly conditions and the introduction of exogenous small molecules to control the assembly of the FF-based peptide molecules, the shape, structure and function of the peptide-based assembly materials have been successfully achieved. These studies not only enrich the assembly structure of FF-based peptide molecules , But also provide new strategies and important experimental evidences for the preparation of other peptide-based nanomaterials and the development of bio-functional materials.