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目的探讨宫颈阴道分泌物胎儿纤维连接蛋白(fetal fibronection,f FN)预测宫颈扩张双球囊引产的效果及其相关性。方法研究对象为2014年1月至2015年12月住院的100例有引产要求及指征的初产孕妇,引产采用宫颈扩张双球囊促宫颈成熟,在放置宫颈双球囊后的12 h内每隔2 h取宫颈阴道分泌物,以固相免疫法测定宫颈阴道分泌物f FN水平,并进行统计分析。结果宫颈阴道分泌物检测显示f FN阳性者58例(f FN阳性组),阴性者42例(f FN阴性组),且两组对象年龄、孕周、宫颈Bishop评分及妊娠并发症、病理妊娠方面比较无统计学差异(P均>0.05)。58例f FN阳性者中成功引产55例(94.8%),42例f FN阴性者中成功引产26例(61.9%),f FN阳性组成功引产率高于f FN阴性组(P<0.05);f FN阳性组阴道分娩率(86.2%)高于f FN阴性组(69.0%),差异有统计学意义(P<0.05)。结论宫颈阴道分泌物f FN可用来预测宫颈扩张双球囊引产效果。
Objective To investigate the effect of cervical vaginal secretions fetus fibronectin (f FN) on prediction of induced dilatation of cervical dilatation and its correlation. Methods The object of study was 100 primiparous pregnant women who were admitted to hospital from January 2014 to December 2015. The pregnant women were asked to use the double dilatation of cervical dilatation to promote cervical ripening. Within 12 h after placement of double dural balloon Cervical vaginal secretions were taken every 2 hours, and the level of f FN in vaginal secretions of the cervix was determined by solid phase immunoassay and statistical analysis was performed. Results Cervix vaginal secretion examination showed that f FN positive in 58 cases (f FN positive group), negative in 42 cases (f FN negative group), and the two groups of subjects age, gestational age, cervical Bishop score and pregnancy complications, pathological pregnancy There was no statistical difference (all P> 0.05). Fifty-eight patients (94.8%) successfully induced induction of f FN positive in 58 cases, 26 (61.9%) successful induction of labor in 42 cases f fN negative, and the successful induction rate of f FN positive was higher than that of f FN negative (P <0.05) ; The vaginal delivery rate in f FN positive group (86.2%) was higher than that in f FN negative group (69.0%), the difference was statistically significant (P <0.05). Conclusion Cervix vaginal secretions f FN can be used to predict the effect of double dilatation of the cervix.