下述事实支持胰蛋白酶或其它蛋白水解酶在无对抗物作用时能够损伤肺组织的理论:具有人的肺气肿生理学特点的全小叶性肺气肿可在动物吸入选择性破坏弹性硬蛋白的番木瓜蛋白酶气溶胶后产生,狗吸入人的白细胞匀浆气溶胶也能产生肺气肿。白细胞就是能够损害α_1-抗胰蛋白酶缺乏患者肺组织的酶的主要来源。实际上α_1-抗胰蛋白酶是人粒细胞中含有的弹力蛋白酶有效的抑制剂,而且α_1-抗胰蛋白酶也抑制 The fact that trypsin or other proteolytic enzymes support lung tissue damage without antagonistic effects is supported by the fact that whole-lobe emphysema, which has the physiological characteristics of human emphysema, can be inhaled by animals in the selective destruction of elastin Papain protease aerosol generated, dog inhaled human leukocyte homogenate aerosol can also produce emphysema. Leukocytes are a major source of enzymes that can damage lung tissue in patients with alpha-1 antitrypsin deficiency. Actually, α 1-antitrypsin is a potent inhibitor of elastase contained in human granulocytes, and α 1-antitrypsin also inhibits