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长期用硝酸酯类药物均产生耐药性.本文旨在观察卡托普利(Cap)能否防止消心痛(ID)耐药性和加强其抗心绞痛作用.1对象与方法按WHO诊断标准确诊的冠心病稳定型心绞痛患者48例,心绞痛发作≥次/周.用随机单盲交叉对照方式进行为期14周、分4期的观察.第1、3期各1周,用维生素C安慰治疗.第1期末将患者随机分为A、B两组各24例,两组间的性别(男性分别为18例与16例)、平均年龄(54.9岁与56.8岁)及平均病程(4.7年与4.4年)均无显著差异(P>0.05).A组第2期(第2～7周)服ID(山东博山制药厂产)5mg,日3次,3日后加至10mg,日3次;第4期(第9～14周)服ID(用法同前)+Cap(上海施贵宝药厂产)6.25mg,日3次,3日后酌情加至12.5mg～25.0mg,日3次.B组第2期用ID+Cap,第4期用ID,用法同前.心绞痛发作时,患者可含服硝酸甘油片并计算每周用量,但不用其它扩血管药.
Long-term use of nitrate drugs have drug resistance.This paper aims to observe the captopril (Cap) can prevent anti-idiopathic pain (ID) resistance and enhance its role in anti-angina.1 objects and methods according to WHO diagnostic criteria Of patients with stable angina pectoris of coronary heart disease in 48 cases, angina pectoris ≥ times / week with a randomized single-blind cross-control mode for a period of 14 weeks, divided into 4 periods of observation.First and third weeks of each 1 week, with vitamin C comfort treatment. At the end of the first period, patients were randomly divided into A group and B group, with 24 cases in each group. There were 18 males and 16 females in the two groups, mean age (54.9 years and 56.8 years) and mean duration (4.7 years and 4.4 years) Year) were not significantly different (P> 0.05) .A group 2 (2 to 7 weeks) service ID (Shandong Boshan Pharmaceutical Factory) 5mg, 3 times a day, 3 days later added to 10mg, 3 times a day; The first 4 (9 ~ 14 weeks) service ID (use the same front) + Cap (Shanghai Squibb pharmaceutical production) 6.25mg, 3 times a day, after 3 days, as appropriate, to 12.5mg ~ 25.0mg, 3 times a day.B group The second phase ID + Cap, the fourth phase ID, usage the same as before. Angina pectoris, the patient can be served with nitroglycerin tablets and calculate weekly dosage, but no other vasodilators.