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目的:检测直肠癌组织存活素(Survivin)和β-连接素(β-catenin)表达状况,探讨其与直肠癌复发、转移的相关性。方法:应用免疫组化SP法检测60例直肠癌组织、10例直肠腺瘤组织及10例癌旁正常黏膜组织Survivin和β-cate-nin的表达。结果:Survivin在直肠癌组织、腺瘤组织和正常组织中的阳性表达率分别为90%、80%和20%;β-catenin在直肠癌组织、腺瘤组织和正常组织中的异常表达率分别为76.7%、50%和10%。Survivin的表达与性别、年龄、肿瘤形态及部位、CEA、分化程度无关,P>0.05;与Duke分期和淋巴结转移相关,P<0.05。β-catenin的异常表达与性别、年龄、肿瘤形态及部位、CEA无关,P>0.05;与分化程度、淋巴结转移、Duke分期相关,P<0.05。Survivin高表达及β-catenin异位表达在直肠癌中呈正相关,r=0.362,P<0.01。结论:Survivin和β-catenin高表达可能与直肠癌的复发和转移有密切关系。
OBJECTIVE: To detect the expression of Survivin and β-catenin in rectal cancer and to investigate its correlation with the recurrence and metastasis of rectal cancer. Methods: The expressions of Survivin and β-cate-nin in 60 cases of rectal cancer, 10 cases of rectal adenoma and 10 cases of adjacent normal mucosa were detected by SP immunohistochemistry. Results: The positive rates of Survivin expression in rectal cancer tissues, adenoma tissues and normal tissues were 90%, 80% and 20% respectively. The abnormal expression rates of β-catenin in rectal cancer tissues, adenoma tissues and normal tissues were 76.7%, 50% and 10%. The expression of Survivin had no correlation with gender, age, tumor morphology and location, CEA, degree of differentiation, P> 0.05, but correlated with Duke staging and lymph node metastasis, P <0.05. The abnormal expression of β-catenin was not associated with gender, age, tumor morphology and location, CEA, P> 0.05; it was correlated with the degree of differentiation, lymph node metastasis and Dukes stage, P <0.05. Survivin overexpression and ectopic expression of β-catenin were positively correlated in rectal cancer (r = 0.362, P <0.01). Conclusion: The high expression of Survivin and β-catenin may be closely related to the recurrence and metastasis of rectal cancer.