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目的 探讨儿童原发性肾病综合征 (肾病 )医院感染的危险因素及其防治措施。方法 收集 190例 1991～ 1999年肾病患儿住院病例 ,采用单因素分析及Logistic多因素回归模型回顾性分析各危险因素的分布。结果 肾病医院感染发生率 34 2 % (6 5 /190 ) ,其中呼吸道感染占 6 9 7%。单因素分析危险因素为 2 4h每公斤体重尿蛋白定量 (尿蛋白 )、住院时间、激素使用时间、抗生素使用种数及时间。多因素分析危险因素为尿蛋白、使用抗生素种数及时间。结论 加强呼吸道疾病管理、建立洁净病房、合理使用抗生素是降低医院感染发生率的重要措施 ;肾病确诊后应足量足疗程使用肾上腺皮质激素以尽快减少蛋白从尿中的丢失。
Objective To investigate the risk factors and preventive measures of nosocomial infection in children with primary nephrotic syndrome (nephropathy). Methods A total of 190 hospitalized children with nephrotic syndrome were collected from 1991 to 1999. The distributions of risk factors were retrospectively analyzed by univariate analysis and Logistic multivariate regression analysis. Results The incidence of nephrotic nosocomial infection was 34 2% (65/190), of which respiratory infection accounted for 69.7%. Univariate analysis of risk factors for 24 h urinary protein per kg body weight (urine protein), length of stay, hormone use, antibiotic use of species and time. Multivariate analysis of risk factors for urinary protein, the use of antibiotic species and time. Conclusion Strengthening respiratory disease management, establishing clean wards, and rational use of antibiotics are important measures to reduce the incidence of nosocomial infections. After adequate diagnosis and treatment of renal diseases, adequate doses of corticotrope should be used to reduce protein loss from the urine as soon as possible.