肠道黏膜免疫系统异常反应所致的炎症反应在炎症性肠病(IBD)的发病中起重要作用。糖皮质激素(GC)是治疗IBD的常用药物,其通过与糖皮质激素受体(GR)结合来调节细胞内基因的表达,进而产生一系列生物学效应。现已发现人类GR与IBD的发生以及GC的治疗反应密切相关,本文就此作一综述。 Inflammatory reaction caused by abnormal reaction of intestinal mucosa immune system plays an important role in the pathogenesis of IBD. Glucocorticoids (GCs) are commonly used drugs for the treatment of IBD that regulate the expression of intracellular genes by binding to the glucocorticoid receptor (GR), resulting in a series of biological effects. It has been found that human GR is closely related to the occurrence of IBD and the response to treatment with GC, and is reviewed in this article.