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目的:评价心外膜脂肪组织厚度和冠状动脉疾病的相关性。方法:计算机检索PubMed、The Cochrane Library、EMbase、CBM、CNKI、VIP及WanFang Data,检索时限均为建库至2015年10月,收集关于心外膜脂肪组织厚度与冠状动脉疾病相关性的病例对照研究。由2位研究者按照纳入和排除标准独立筛选文献、提取资料和评价质量后,用STATA12.0软件进行Meta分析。结果:共纳入14个病例对照研究,3 162例研究对象,其中2 054例冠状动脉疾病患者,1 108例非冠状动脉疾病者。Meta分析显示:患冠状动脉疾病组的心外膜脂肪组织厚度大于无冠状动脉疾病者,它们之间的差异有统计学意义(SMD=0.67,95%CI:0.38~0.97,P=0.000)。结论:基于目前研究结果,可以确定心外膜脂肪组织厚度与冠状动脉疾病存在相关性,可能是一个评价冠心病风险的辅助指标。
Objective: To evaluate the relationship between epicardial adipose tissue thickness and coronary artery disease. METHODS: PubMed, The Cochrane Library, EMbase, CBM, CNKI, VIP and WanFang Data were searched by computer. The retrieval time was from the establishment of the database to October 2015, and the case-control of the correlation between epicardial adipose tissue thickness and coronary artery disease was collected the study. Two researchers independently screened the literature according to inclusion and exclusion criteria, extracted data and evaluated the quality, and then performed the meta-analysis with STATA12.0 software. Results: A total of 14 case-control studies were included and 3,162 subjects were enrolled, including 2 054 patients with coronary artery disease and 1 108 non-coronary artery disease. Meta-analysis showed that the thickness of epicardial adipose tissue in patients with coronary artery disease was significantly higher than those without coronary artery disease (SMD = 0.67,95% CI: 0.38-0.97, P = 0.000). CONCLUSIONS: Based on current findings, it is possible to determine the association of epicardial adipose tissue thickness with coronary artery disease and may be an adjunct to the risk of coronary heart disease.