Ti3C2Tx has been emerging as an attractiveplatform to prepare compositecatalysts,and theirassembly into integrated catalytic materials represents a key step forward toward practical applications. However, the swelling behavior of Ti3C2Tx leads to significant structure change, which challenges the stability of Ti3C2Tx-basedintegratedfunctionalmaterialsforcatalyticapplications.Herewereportafacilesynthesis of Pd/Ti3C2Tx?graphene hydrogels in which Pd/Ti3C2Tx are spatially encapsulated in the 3D porous graphene framework. The porous interconnected structure not only affords efficient mass transfer and desirable functional accessibility to catalytic active sites, but also effectively buffers the swelling behavior of Ti3C2Tx. When applied for catalytic hydrogenation of nitroaromatic compounds, the mechanically robust Pd/Ti3C2Tx?graphene hydrogels exhibit efficient activities, easy separability, and good cyclability. This work is expected to promote the application of Ti3C2Tx-based functional materials for practical applications involving interactions with salt solutions, such as supercapacitors, catalysis, and water purification.