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目的:探讨急性脑梗死患者外周血清同型半胱氨酸(Hcy)、白细胞介素10(IL-10)及血清基质金属蛋白酶-9(MMP-9)与脑梗死体积的关系。方法:选择急性脑梗死患者125例为观察对象,同期健康体检者为健康对照组(37例)。以ELISA法测定患者外周血清Hcy、IL-10及MMP-9水平;急性脑梗死患者按梗死体积被分为小梗死组(≤5cm,47例),中梗死组(5~15cm,41例),大梗组(≥15cm,37例);比较不同梗死体积Hcy、IL-10及MMP-9水平的变化。结果:与健康对照组比较,急性脑梗死组患者MMP-9、Hcy水平显著升高;IL-10显著降低。外周血清Hcy水平:大梗死组的显著高于小梗死组和中梗死组[(18.5±4.2)μmol/L比(16.11±3.5)μmol/L、(16.79±3.4)μmol/L、P<0.01,P<0.05];外周血清MMP-9水平:大梗死组及中梗死组的均明显高于小梗死组[(256±35)ng/ml、(238±26)ng/ml比(164±35)ng/ml,P<0.01,P<0.05];IL-10水平:大梗死组的明显低于小梗死和中梗死组[(0.31±0.12)ng/ml、(0.59±0.15)ng/ml比(0.60±0.17)ng/ml,P均<0.01]。结论:同型半胱氨酸、白细胞介素10及血清基质金属蛋白酶-9水平与急性脑梗死的发病有关系,可反映脑梗死的危险程度。
Objective: To investigate the relationship between peripheral blood serum homocysteine (Hcy), interleukin 10 (IL-10) and serum matrix metalloproteinase-9 (MMP-9) and infarct volume in patients with acute cerebral infarction. Methods: A total of 125 patients with acute cerebral infarction were selected as the observation subjects and the healthy controls were selected as healthy control group (n = 37). Serum levels of Hcy, IL-10 and MMP-9 were measured by ELISA. Patients with acute cerebral infarction were divided into small infarction group (≤5cm, 47 cases) and middle infarction group (5 ~ 15cm, 41 cases) (≥15 cm, 37 cases). The changes of Hcy, IL-10 and MMP-9 in different infarct volume were compared. Results: Compared with the healthy control group, the levels of MMP-9 and Hcy in patients with acute cerebral infarction were significantly increased and IL-10 was significantly decreased. The level of Hcy in peripheral blood was significantly higher in large infarction group than in small infarction group and middle infarction group [(18.5 ± 4.2) μmol / L vs (16.11 ± 3.5) μmol / L, P <0.01 , P <0.05]. The level of serum MMP-9 in peripheral blood was significantly higher in small infarction group than in small infarction group [(256 ± 35) ng / ml, (238 ± 26) ng / (0.31 ± 0.12) ng / ml, (0.59 ± 0.15) ng / ml, P <0.05); The level of IL-10 in the large infarction group was significantly lower than that in the small infarction and middle infarction group [ ml ratio (0.60 ± 0.17) ng / ml, P <0.01]. Conclusion: The levels of homocysteine, interleukin-10 and serum matrix metalloproteinase-9 correlate with the incidence of acute cerebral infarction and may reflect the risk of cerebral infarction.