近20～30年来革兰阴性细菌引起小儿感染性休克的发病率急剧上升,除脑膜炎双球菌较多者外,其次则以杆菌引起者为多,内毒素是革兰氏阴性细菌胞壁成分,细菌死亡之后释出,是引起患者休克的原因。材料、方法和结果雄性家兔、体重1.68公斤,通过记纹鼓观察血压,通过眼底镜检查家兔眼底及家兔耳部微循环,给家兔静脉注入福氏痢疾杆菌 The incidence of septic shock caused by Gram-negative bacteria in children in recent 20 ~ 30 years has risen sharply. In addition to more patients with meningococcus, followed by bacteria caused by bacilli, endotoxin is the component of Gram-negative bacterial cell wall , Released after the death of bacteria, is the cause of shock in patients. MATERIALS, METHODS AND RESULTS Male rabbits, weighing 1.68 kg, were observed for blood pressure through a guinea pig drum, fundus oculi of the rabbits were examined with ophthalmoscopy, and ear microcirculation in rabbits was observed. The rabbits were intravenously infused with Shigella flexneri