p16、cdk4 在肿瘤分子生物学中的研究较成熟 ,但对中耳胆脂瘤作用的研究较少。现将近年有关抑癌基因p16细胞周期研究 ,中耳胆脂瘤上皮细胞增殖与凋亡的研究 ,以及p16及cdk4 在胆脂瘤形成中作用的研究进展作一综述。 The research of p16 and cdk4 in tumor molecular biology is relatively mature, but few studies on the effect of middle ear cholesteatoma. In recent years, the research on the cell cycle of tumor suppressor gene p16, the proliferation and apoptosis of middle ear cholesteatoma epithelial cells, and the research progress of p16 and cdk4 on the formation of cholesteatoma are reviewed.