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[目的]观察半夏泻心汤联合米氮平治疗特发性胃轻瘫的临床效果。[方法]将68例特发性胃轻瘫患者随机分为试验组和对照组。试验组予半夏泻心汤联合米氮平治疗,对照组单用米氮平治疗,2组患者均治疗4周。采用胃轻瘫基本症状指数(GCSI)和中医证候量表观察患者临床症状和胃感觉功能的变化情况,评估临床疗效并观察不良事件。[结果]试验组和对照组的总有效率分别为88.2%和64.7%(P<0.05)。治疗后,2组患者的GCSI评分均有改善;试验组患者胀气评分与对照组差异有统计学意义(P<0.05)。2组患者不良反应比较,差异无统计学意义(P>0.05)。[结论]半夏泻心汤联合米氮平可能对特发性胃轻瘫有效。
[Objective] To observe the clinical effect of Banxiaxiexin Decoction combined with mirtazapine in the treatment of idiopathic gastroparesis. [Methods] 68 patients with idiopathic gastroparesis were randomly divided into experimental group and control group. The experimental group was treated with Banxiaxiexin Decoction combined with mirtazapine and the control group with mirtazapine alone. The two groups were treated for 4 weeks. The changes of clinical symptoms and gastric sensory function were observed by GCSI and TCM Syndrome Scale, and the clinical effects were evaluated and the adverse events were observed. [Results] The total effective rates of the experimental group and the control group were 88.2% and 64.7%, respectively (P <0.05). After treatment, the GCSI scores of both groups improved; the flatulence score of the test group was significantly different from that of the control group (P <0.05). There was no significant difference in adverse reactions between the two groups (P> 0.05). [Conclusion] Banxiaxiexin Decoction combined with mirtazapine may be effective for idiopathic gastroparesis.