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目的:探讨冷极射频消融术治疗放化疗后进展的非小细胞肺癌的疗效及安全性。方法:选择30例放、化疗后进展的非小细胞肺癌患者,CT引导下采用冷极射频消融治疗,术后1个月和每3个月复查CT观察有无残留和复发,必要时可多次治疗,通过影像学评价疗效,观察术中、术后并发症。结果:30例患者在CT引导下消融针均准确穿刺,进入肿瘤预定位置并顺利完成消融过程,未见严重并发症。行冷极射频术后1个月复查胸部CT发现大多数肿瘤较术前有不同程度的缩小、坏死、密度减低。根据影像学表现,肿瘤完全坏死10.0%(3/30),不完全坏死40.0%(12/30),部分坏死23.3%(7/30),总有效率73.3%(22/30)。结论:冷极射频消融术是肺癌治疗行之有效的治疗措施之一,疗效确切、安全可靠、创伤小,并可重复治疗。
Objective: To investigate the efficacy and safety of cryopolar radiofrequency ablation in the treatment of advanced non-small cell lung cancer after radiotherapy and chemotherapy. METHODS: Thirty patients with non-small cell lung cancer who progressed after chemotherapy and radiotherapy were selected. CT-guided cryoradiofrequency ablation was performed. CT and CT scans were performed at 1 month and every 3 months to observe whether there were residual and recurrence. The second treatment was to evaluate the efficacy by imaging and to observe the intraoperative and postoperative complications. RESULTS: Thirty patients underwent CT-guided ablation needles with accurate puncture, entered the tumor site and successfully completed the ablation procedure. No serious complications were seen. A review of chest CT at 1 month after radiofrequency magnetic resonance showed that most tumors had different degrees of reduction, necrosis, and reduced density compared with preoperative ones. According to imaging findings, the tumor completely necrosed by 10.0% (3/30), incomplete necrosis 40.0% (12/30), partial necrosis 23.3% (7/30), and total effective rate 73.3% (22/30). Conclusion: The cryopolaris radiofrequency ablation is one of the effective treatment measures for the treatment of lung cancer. It has definite curative effect, safety, reliability, minimal trauma, and can be treated repeatedly.