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目的:探讨骨髓增生异常综合征难治性贫血(myelodysplastic syndrome,refractory anemia简称MDS-RA)与巨幼细胞性贫血(megalobastic anemia简称MA)的形态特点。方法:回顾分析29例MDS-RA和98例MA的血象、骨髓象及小巨核细胞染色的形态学特点。结果:MDS-RA和MA血象均表现不同程度的血细胞减少;MDS-RA骨髓象以中晚幼红细胞为主,MA易见各阶段巨幼红细胞,MDS-RA和MA的病态造血各有其特点,MDS-RA淋巴样小巨核细胞检出率显著高于MA。结论:MDS-RA与MA形态既有相同点又各有特点,而这些特点为两者的鉴别诊断提供依椐。
Objective: To investigate the morphological characteristics of myelodysplastic syndrome (MDS-RA) and megalobastic anemia (MA). Methods: The morphological characteristics of 29 cases of MDS-RA and 98 cases of MA were analyzed retrospectively. Results: The MDS-RA and MA blood showed different degrees of cytopenia. The bone marrow of MDS-RA was predominantly middle-late erythroblasts. MA was easy to see in all stages of megaloblastic cells. The morbid hematopoiesis of MDS-RA and MA had their own characteristics , The detection rate of MDS-RA lymphoid small megakaryocytes was significantly higher than that of MA. Conclusion: MDS-RA and MA morphology both have the same point and each have their own characteristics, and these characteristics provide the basis for the differential diagnosis between the two.