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目的对新疆维吾尔族16名优秀耐力运动员和153名普通人ACE基因I/D多态性和血清ACE活性与有氧运动能力进行关联研究。方法聚合酶链反应(PCR)和分光光度计法。结果1)新疆维吾尔族耐力运动员ACE基因3种基因型和等位基因分布频率与普通人组比较,存在显著差异(P<0.05),与南方汉族优秀中长跑运动员、北方汉族优秀耐力运动员和Caucasians优秀耐力运动员均未见显著差异(P>0.05),其中II基因型和I等位基因出现频率最高。2)新疆维吾尔族普通人群与南方和北方汉族普通人群3种基因型和等位基因分布频率比较,均存在显著差异(P<0.05),与Caucasians普通人群相比,不存在显著性差异(P>0.05)。3)新疆维吾尔族耐力运动员与对照人群ACE活性不存在显著差异(P>0.05),ACE活性II>ID>DD。结论拥有II基因型或I等位基因的维吾尔族运动员,可能属于运动训练敏感的高反应群体;维吾尔族虽然是一个融合民族,依据本研究推断其遗传背景更接近Caucasians人;维吾尔族拥有II基因型或I等位基因的人血清ACE活性低,这表明运动能力与ACE活性呈负相关,其机制有待进一步研究。
Objective To investigate the relationship between ACE gene I / D polymorphism and serum ACE activity and aerobic capacity in 16 Uygur elite endurance athletes and 153 common people in Xinjiang Uygur Autonomous Region. Methods Polymerase chain reaction (PCR) and spectrophotometry. Results 1) There was significant difference (P <0.05) in the distribution frequency of ACE genotypes and alleles in Xinjiang Uygur endurance athletes compared with the normal people, which was significantly different from that of the excellent athletes of the South Han excellent middle and long distance runners, the North Han excellent endurance athletes and the Caucasians There was no significant difference between elite endurance athletes (P> 0.05), of which genotype II and I allele had the highest frequency. 2) There was significant difference (P <0.05) in the genotype distribution and allele distribution between the Uygur common people in Xinjiang and the common people in South and North Han nationality, but there was no significant difference compared with the Caucasians > 0.05). 3) There was no significant difference in ACE activity between Uygur endurance athletes and control subjects in Xinjiang (P> 0.05), ACE activity II> ID> DD. Conclusion Uyghur athletes with II genotype or I allele may belong to exercise-sensitive high-response groups. Although Uyghur people are a fusion race, the genetic background of Uighur people is closer to Caucasians based on this study. Uyghur people have II gene Type I or I alleles of human serum ACE activity is low, indicating that exercise capacity and ACE activity was negatively correlated, the mechanism remains to be further studied.