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①目的探讨雌激素受体（ＥＲ）与胃腺癌的发生及其生物学行为之间的关系。②方法应用葡聚糖包裹活性炭饱和分析法，检测了４０例胃腺癌及其远隔胃粘膜组织中ＥＲ的含量。③结果４０例胃癌组织中７例ＥＲ阳性，含量为１５５．４±９１．０ｆｍｏｌ／ｍｇ蛋白；而远隔胃粘膜组织中未检测到ＥＲ；胃癌组织中ＥＲ阳性率及含量均显著高于远隔粘膜组织（Ｐ＝０．０１；ｔ＝１１．４，Ｐ＜０．０１）。ＥＲ阳性率与胃癌病人的年龄、性别、Ｂｏｒｒｍａｎ分型、肿瘤大小及细胞分化程度，在不同分组间差异均无显著意义（χ２＝０．０６～１．５４，Ｐ均＞０．０５）。④结论ＥＲ在胃粘膜癌变过程中具有一定的作用
Objective To investigate the relationship between estrogen receptor (ER) and the occurrence and biological behavior of gastric adenocarcinoma. 2 Methods dextran-encapsulated activated carbon saturation analysis was used to detect the content of ER in 40 cases of gastric adenocarcinoma and its distant gastric mucosa. 3 Results Of 40 cases of gastric cancer in 7 cases of ER-positive, content of 155.4 ± 91.0fmol / mg protein; and distant gastric mucosa was not detected in ER; gastric cancer tissue ER positive rate and content were significantly higher than the far The mucosal tissues (P=0.01; t=11.4, P<0.01). The positive rate of ER and gastric cancer patients’ age, gender, Borrman type, tumor size and cell differentiation were not significantly different in different groups (χ2=0.06-1.54, P>0.05). 4 Conclusions ER plays a role in gastric carcinogenesis