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本实验观察慢性缺氧幼猪(Ch组)和对照组(C组)对急性缺氧的血流动力学反应及组胺H_1、H_2受体阻断剂扑尔敏、甲氰咪呱的作用。急性缺氧可增加肺动脉压(Ppa),Ch组比C组增加明显(前者增加25mmHg、100%;后者增加17mmHg,83.4%)。缺氧时扑尔敏降Ppa的作用亦为Ch组大于C组(Oh组降11mmHg,C组6mmHg)。甲氰咪呱增Ppa的作用两组相近。结果提示:(1)慢性缺氧能增强HPPR;(2)组胺受体参与HPPR调节;(3)慢性缺氧可能使肺动脉H_1受体活性增强,此变化可能与HPPR增强有关。
This study was designed to observe the effects of chronic hypoxia (Ch) and control (C) on the hemodynamic response to acute hypoxia and the effects of histamine H 1, H 2 receptor blockers chlorpheniramine and cimetidine . Acute hypoxia increased pulmonary arterial pressure (Ppa), and Ch group increased more significantly than C group (former increased 25mmHg, 100%; latter increased 17mmHg, 83.4%). The role of chlorpheniramine lowering Ppa in hypoxia was also greater in Ch group than in C group (Oh group decreased 11mmHg, C group 6mmHg). Cimetidine increases the role of Ppa similar to the two groups. The results suggest that: (1) chronic hypoxia can enhance HPPR; (2) histamine receptors involved in HPPR regulation; (3) chronic hypoxia may increase pulmonary artery H 1 receptor activity, this change may be associated with increased HPPR.