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目的:探讨纳洛酮对于新生儿缺氧缺血性脑病治疗的效果。方法:96例缺氧缺血性脑病新生儿,随机分为常规组和观察组均48例,常规组给予常规综合治疗,观察组在常规治疗基础上予纳洛酮注射液治疗。结果:两组在呼吸改善时间、惊厥消失时间、体征消失时间比较,观察组均优于常规组(P<0.05)。治疗后常规组有效率79.2%,观察组总有效率93.8%,两组总有效率比较,观察组优于常规组(P<0.05)。结论:纳洛酮治疗新生儿缺氧缺血性脑病效果显著。
Objective: To investigate the effect of naloxone on the treatment of neonatal hypoxic-ischemic encephalopathy. Methods: Ninety-six neonates with hypoxic-ischemic encephalopathy were randomly divided into routine treatment group and observation group (n = 48). The conventional treatment group was given conventional comprehensive treatment. The observation group was treated with naloxone injection on the basis of routine treatment. Results: The two groups were better than the conventional group (P <0.05) in respiration improvement time, disappearance of convulsions and disappearance of signs. After treatment, the effective rate of conventional group was 79.2%, and the total effective rate of observation group was 93.8%. The total effective rate of the two groups was better than that of the conventional group (P <0.05). Conclusion: Naloxone is effective in treating neonatal hypoxic-ischemic encephalopathy.