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目的研究中文版统一肝豆状核变性评分量表(UWDRS)的信度和效度。方法采用翻译和回译将UWDRS翻译为中文版本。应用中文版UWDRS评价110例肝豆状核变性(HLD)患者,评价其信度和效度。结果中文版UWDRS量表总分为31.27(20.656,0~89),神经功能得分为17.53(15.867,0~64),肝脏功能得分为6.46(6.150,0~36),精神症状得分为7.27(6.045,0~26)。量表整体Cronbachα系数为0.967,神经功能为0.975、肝脏功能为0.493、精神症状为0.798。总量表Spearman-Brown系数为0.811,神经功能为0.941,肝脏功能为0.392,精神症状为0.775。总量表2次测定的重测相关系数为0.968,神经功能为0.970、肝脏功能为0.628、精神症状得分为0.823(均P<0.001);总量表的两位评定者间相关系数为0.920,神经功能为0.927,肝脏功能为0.584,精神症状得分为0.676(均P<0.001)。结构效度没有只出现3个明确的因子,但有6个因子解释了总变异的50.685%。总量表的平均量表水平内容效度指数(S-CVI/Ave)值为0.99。结论中文版UWDRS具有良好的信度和效度,但部分内容尚需进一步修订。
Objective To study the reliability and validity of the Chinese version of the Unified Wilson’s Disease Rating Scale (UWDRS). Methods UWDRS was translated into Chinese using translation and backtracking. 110 Chinese patients with hepatolenticular degeneration (HLD) were evaluated with Chinese version of UWDRS to evaluate their reliability and validity. Results The total score of Chinese version of UWDRS scale was 31.27 (20.656,0 ~ 89), the score of neurological function was 17.53 (15.867,0.64), the score of liver function was 6.46 (6.150,0.66) and the score of psychiatric symptom was 7.27 6.045,0 ~ 26). The overall Cronbach alpha coefficient was 0.967, neurological function was 0.975, liver function was 0.493, and psychiatric symptoms were 0.798. The Spearman-Brown coefficient of the total scale was 0.811, the neurological function was 0.941, the liver function was 0.392, and the psychiatric symptom was 0.775. The correlation coefficient of retesting was 0.968, the neurological function was 0.970, the liver function was 0.628, and the mental symptom score was 0.823 (all P <0.001). The correlation coefficient between the two scales of the total scale was 0.920, The neurological function was 0.927, the liver function was 0.584, and the psychiatric symptom score was 0.676 (all P <0.001). Structural validity did not appear only three clear factors, but six factors explained 50.685% of the total variation. The average scale of the total scale The content-validity index (S-CVI / Ave) value is 0.99. Conclusion The Chinese version of UWDRS has good reliability and validity, but some of the contents still need further revision.