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肠易激综合征(IBS)是一种慢性功能性肠道疾病,其发病率呈上升趋势,其发病主要特点是内脏高敏感性增高,但其神经生物学机制尚不完全清楚,因此对其发病机制研究有较重要意义。研究表明,神经胶质细胞在内脏痛反应中可能起较为重要作用,尤其是脊髓中支配左半结肠的骶髓后连合核团中神经胶质细胞与IBS内脏高敏感性可能具有密切相关性。本文拟于对神经胶质细胞在IBS内脏高敏感性中作用的研究进展作一综述。
Irritable bowel syndrome (IBS) is a chronic functional bowel disease with an increasing incidence. The main feature of IBS is the increased visceral hypersensitivity, but its neurobiological mechanism is not fully understood. Therefore, The pathogenesis of research is more important. Studies have shown that glial cells may play a more important role in the visceral pain response. In particular, glial cells in the dorsal sacral spinal dorsal sac in the spinal cord may be closely related to visceral hypersensitivity of IBS . This article is intended to review the role of glial cells in the visceral hypersensitivity of IBS.