蛋白尿一直被认为是肾脏和心血管疾病的进展标志。近年的研究表明,超滤液中的蛋白是导致肾脏功能恶化的一个独立因素。动物和临床实验都表明,蛋白和白蛋白对近端小管上皮细胞有直接毒性,可导致间质炎症和纤维化。肾小管摄入白蛋白可能是慢性肾脏疾病发生和发展的重要因素。近端 Proteinuria has long been recognized as a hallmark of renal and cardiovascular disease progression. Recent studies have shown that the ultrafiltrate protein is an independent factor leading to deterioration of renal function. Both animal and clinical trials have shown that proteins and albumin are directly toxic to proximal tubule epithelial cells and can lead to interstitial inflammation and fibrosis. Tubular intake of albumin may be an important factor in the occurrence and development of chronic kidney disease. Near the end