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目的 :通过对类风湿关节炎 (RA)活动性指标血清白介素 - 2 (IL - 2 )、可溶性白介素 - 2受体 (sIL -2R)、透明质酸 (HA)、血管内皮生长因子 (VEGF)水平变化的测定 ,探讨它们与病情活动的相关性及临床意义。方法 :采用RIA和ELISA法对类风湿关节炎患者活动组、缓解组及正常对照组进行IL - 2、sIL - 2R、HA、VEGF测定 ,并从敏感性、特异性方面进行比较分析。结果 :活动组RA患者血清sIL - 2R、HA、VEGF的含量显著高于缓解组及正常对照组 (p <0 0 1 ) ,而活动组RA患者血清IL - 2的含量却显著低于缓解组及正常对照组 (p <0 0 1 )。VEGF的特异性最强 (93 3% ) ,敏感性为 93 3%。 结论 :与血清IL - 2、sIL - 2R、HA相比 ,血清VEGF水平测定更有助于类风湿关节炎活动性的监测 ,对该病的治疗及预后均有一定的意义
Objective: To investigate the effects of rheumatoid arthritis (RA) on serum levels of interleukin - 2, soluble interleukin - 2 receptor (sIL - 2R), hyaluronic acid (HA), vascular endothelial growth factor Level changes in the determination of their relationship with the disease activity and clinical significance. Methods: The levels of IL - 2, sIL - 2R, HA and VEGF were determined by RIA and ELISA in the active group, remission group and normal control group of rheumatoid arthritis patients. The sensitivity and specificity were compared. Results: The levels of sIL - 2R, HA and VEGF in active RA patients were significantly higher than those in remission patients and normal controls (p <0.01), while those in active patients were significantly lower than those in remission patients And normal control group (p <0.01). The strongest specificity of VEGF (93 3%) was 93 3%. Conclusion: Compared with serum IL - 2, sIL - 2R and HA, the determination of serum VEGF is more helpful for the monitoring of rheumatoid arthritis activity, which has certain significance for the treatment and prognosis of the disease