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目的研究类风湿关节炎(RA)患者外周血25羟维生素D3[25-(OH)D3]水平与疾病的相关性。方法 ELISA法检测72例绝经后女性RA患者(RA组)和58例健康的绝经后女性志愿者(对照组)外周血25-(OH)D3的水平,并采用疾病活动性评分(DAS28)评估RA患者疾病活动性,比较两组间25-(OH)D3水平的差异及25-(OH)D3与RA活动性之间的关系。结果与对照组相比,RA患者外周血25-(OH)D3水平明显降低(P<0.05),且25-(OH)D3水平与DAS28呈负相关。结论维生素D在类风湿关节炎疾病诊治过程中,可能起到防治及病情评估的双重作用。
Objective To investigate the relationship between 25-hydroxyvitamin D3 [25- (OH) D3] and the disease in patients with rheumatoid arthritis (RA). Methods Serum levels of 25- (OH) D3 in peripheral blood of 72 postmenopausal women with RA (RA group) and 58 healthy postmenopausal women (control group) were measured by ELISA. Disease activity score (DAS28) The disease activity of RA patients was compared. The difference of 25- (OH) D3 level between the two groups and the relationship between 25- (OH) D3 and RA activity were compared. Results Compared with the control group, the level of 25- (OH) D3 in peripheral blood of RA patients was significantly decreased (P <0.05), and the level of 25- (OH) D3 was negatively correlated with DAS28. Conclusion Vitamin D may play a dual role in prevention and treatment of disease during diagnosis and treatment of rheumatoid arthritis.