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目前治疗溃疡性结肠炎(ulcerative colitis,UC)的主要药物仍为氨基水杨酸类和皮质类固醇类,现就其临床应用介绍如下: 1 氨基水杨酸类药 1.1 柳氮磺胺吡啶(sulfasalazine,SASP) 1.1.1 临床应用 SASP是目前治疗溃疡性结肠炎的首选药物,经口服后在肠道菌丛的偶氮还原酶作用下,SASP裂解为5-氨基水杨酸(5-ASA)和磺胺吡啶(SP)。5-ASA是其主要的有效成分,SASP主要用于轻、中型溃疡性结肠炎的治疗,对于重症病例多与激素类药物联用,因为SASP的代谢与正常肠道菌群有关,如同时服用抗生素就会延缓此药的分解代谢;硫酸亚
At present, the main drugs for the treatment of ulcerative colitis (UC) are still aminosalicylates and corticosteroids. The clinical application of them is as follows: 1 Aminosalicylates 1.1 Sulfasalazine, SASP) 1.1.1 Clinical application SASP is the first choice of drug for treating ulcerative colitis. After oral administration, SASP cleaves to 5-aminosalicylic acid (5-ASA) under the action of azo-reductase in intestinal flora Sulfapyridine (SP). 5-ASA is its main active ingredient, SASP is mainly used for the treatment of mild and moderate ulcerative colitis, more severe cases and hormone drugs, because the SASP metabolism and normal intestinal flora, such as taking at the same time Antibiotics will delay the catabolism of this medicine;