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目的 探讨前列腺增生 (BPH)的 3种外科治疗方法血清 IL- - 6和 CRP水平的变化 .方法 用前瞻、对比的临床实验 ,对 117例分别进行开放性手术 (OP)、经尿道气化电切术(TUEVAP)和组织间激光消融 (IL C)的 BPH患者 ,用酶联免疫吸附法 (EL ISA )检测其手术前后血清白细胞介素 - 6 (IL - 6 )和 C-反应蛋白 (CRP)水平 .结果 3组患者血清 IL- 6和 CRP水平术前无显著差异 ,但术后 2 4 h明显高于术前 (P<0 .0 5 ) ,其中以开放手术组最高 ,TUEVAP组次之 ,IL C组最低 ;术后2 4 h血清 IL - 6水平与手术时间、术中出血量明显相关 (r=0 .6 9,P=0 .0 0 0 0 ) ,术后 4 8h血清 CRP水平与手术时间相关 (r= 0 .83,P=0 .0 0 0 0 ) .结论 3种外科治疗方法中 ,开放性手术对机体的创伤最为严重 ,急性时相反应最大 ,经尿道气化电切术次之 ,组织间激光消融则最小 .手术的操作时间和术中出血量是影响机体创伤程度的主要因素
Objective To investigate the changes of serum IL-6 and CRP levels in three kinds of surgical treatment of benign prostatic hyperplasia (BPH) .Methods A prospective and comparative clinical trial was performed in 117 patients with open surgery (OP), transurethral electrovaporization The levels of serum interleukin - 6 (IL - 6) and C - reactive protein (CRP) in patients with BPH undergoing TUEVAP and IL - C were measured by ELISA before and after operation. Results Serum levels of IL-6 and CRP were not significantly different between the three groups before operation, but were significantly higher at 24 hours after operation than those before operation (P <0.05), with the highest in open surgery group and the lowest in TUEVAP group IL - 6 level was significantly correlated with operative time and blood loss at 24 h after operation (r = 0.96, P = 0.000 0). Serum The level of CRP was correlated with the operation time (r = 0.83, P = 0.0000) .Conclusion Among the three kinds of surgical treatment, open surgery has the most severe trauma to the body and the most acute phase response. The transurethral gas Followed by electrosurgery, tissue ablation is the smallest laser surgery time and intraoperative blood loss is the main factor affecting the degree of trauma