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本文检测了140例丙型肝炎病毒(HCV)抗体(抗-HCV)阳性的慢性丙型肝炎(CHC)的HCV核酸(HCVRNA)和IgM抗体(抗-HCVIgM)两项指标。结果表明,原始诊断为不同临床型的肝炎(HC)患者,8年随访时,HCVRNA和抗-HCVIgM阳性率分别为80.7%和90.7%(u=2.39P<0.05).在原始诊断不同临床型HC转慢者中,上述两项指标均未发现统计学上的差别(均为P>0.05)。HCVRNA与抗-HCVIgM配对比较,符合率为78.6%。基因分型初步结果表明,河北省固安HCV以基因Ⅱ型为主。本研究提示,随访8年的CHC患者绝大多数仍有传染性;本文方法检测的抗-HCVIgM不能代表早期感染标志,但代表慢性感染活动化或带毒,所以,在不具备检测HCVRNA的地方更具有实用价值.
In this paper, we detected two HCV RNA (HCV RNA) and IgM antibody (anti-HCVVI) markers in 140 patients with chronic hepatitis C (CHC) positive for hepatitis C virus (HCV). The results showed that the positive rates of HCVRNA and anti-HCVVI were 80.7% and 90.7% (u = 2.39P <0.05) at the 8-year follow-up respectively in patients with originally diagnosed hepatitis (HC) . In the original diagnosis of different clinical type HC slow, these two indicators were found no statistical difference (all P> 0.05). The match of HCV RNA with anti-HCVVI was 78.6%. The preliminary results of genotyping showed that HCV genotype Ⅱ in Gu’an of Hebei Province was the main one. This study suggests that the vast majority of patients with CHC who are followed up for 8 years are still infectious. The anti-HCVVIm detected by this method can not represent early signs of infection but is active or poisonous on behalf of chronic infection. Therefore, More practical value.