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目的:探讨IVF-ET中多胎妊娠减胎术对双胎妊娠结局的影响。方法:回顾性地分析IVF-ET治疗后直接双胎妊娠124例(A组)和IVF多胎妊娠减为双胎妊娠43例(B组),比较二组孕期流产率、早产率、胎儿出生体重、胎儿畸形率、新生儿死亡率、胎盘粘连和产后出血等。结果:早期流产率A组8.1%,B组25.6%;晚期流产率A组16.9%,B组9.3%;总流产率A组25%,B组34.9%;A、B组间流产率有显著差异(P<0.01)。A、B组平均孕周(36.6±2.2周vs36.0±2.9周)、第一胎胎儿出生体重(2678.0±510.3gvs2542.5±454.8g)和第二胎胎儿出生体重(2393.4±496.8gvs2297.5±501.0g)间无统计学差异;A、B组间在母体并发症发生率、胎儿畸形率、新生儿死亡率之间也无统计学差异(P>0.05)。结论:IVF-ET中多胎减为双胎妊娠与IVF-ET中直接双胎妊娠相比,早期流产率明显增加。
Objective: To investigate the effect of IVF-ET on pregnancy outcomes in twin pregnancy. Methods: A retrospective analysis of 124 cases of direct twin pregnancy (group A) and IVF multiple pregnancies to 43 cases of twin pregnancy (group B) after IVF-ET treatment were retrospectively analyzed. The abortion rate, preterm birth rate, , Fetal malformation rate, neonatal mortality, placental adhesion and postpartum hemorrhage. Results: The rate of early abortion was 8.1% in group A, 25.6% in group B, 16.9% in group A, 16.9% in group B, 9.3% in group B, 25% in group A and 34.9% in group B, and the abortion rate was significantly higher in group A and B Difference (P <0.01). The average gestational age in group A and group B was 36.6 ± 2.2 weeks vs36.0 ± 2.9 weeks. The birth weight of the first fetus was 2678.0 ± 510.3gvs2542.5 ± 454.8g and the second birth weight was 2393.4 ± 496.8gvs2297. 5 ± 501.0g). There was no significant difference between A and B groups in the incidence of maternal complications, fetal malformation rate and neonatal mortality rate (P> 0.05). CONCLUSIONS: The rate of multiple abortions to twin pregnancies in IVF-ET is significantly higher in early abortion than in IVF-ET direct twin pregnancies.