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1983年6月至1990年10月我院用马利兰和联合化疗治疗慢性粒细胞白血病(慢粒)16例。报道如下。对象与方法对象治疗组:1983年6月～1990年10月住院确诊的16例初治患者,男8例,女8例;对照组:1976年～1989年住院病人16例,男12例,女4例。根据文献标准均属高危组。方法治疗组中15例以马利兰每日6mg:1例以羟基脲每日2g 诱导缓解。缓解后,以 COAP(长春新碱2mg 静注第0天;环磷酰胺400mg 静注第1天、4天;阿糖胞苷50mg 静注,每12小时1次,第1～5天;强的松每日40mg,第1～5天)、HOAP(三尖杉酯碱每日3mg,静滴第1～5天,其它同上)、
June 1983 to October 1990 in our hospital with Maryland and combined chemotherapy in the treatment of chronic myeloid leukemia (CML) in 16 cases. Reported as follows. Subjects and Methods Subjects Treatment group: 16 cases of newly diagnosed inpatients diagnosed in our hospital from June 1983 to October 1990, 8 males and 8 females; control group: 16 inpatients from 1976 to 1989, 12 males, Female 4 cases. According to the literature standards are high-risk group. Methods In the treatment group, 15 cases were treated with malalion 6 mg daily: 1 case was treated with hydroxyurea 2 g daily to induce remission. After remission, COAP (vincristine 2mg intravenous injection on day 0; cyclophosphamide 400mg intravenous injection on day 1, 4 days; cytarabine 50mg intravenous injection every 12 hours for 1 to 5 days; Of pine daily 40mg, 1 to 5 days), HOAP (harringtonine daily 3mg, intravenous drip 1 ~ 5 days, the other Ibid),