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目的:探讨Lasp1蛋白在乳腺浸润性癌、乳腺导管内癌和正常组织中的表达及其与临床病理因素的关系,并进一步分析其表达对临床预后的影响。方法:应用免疫组织化学(En VisionTM)法分别检测Lasp1蛋白在70例乳腺浸润性癌组织、70例乳腺导管内癌组织和70例正常组织中的表达情况,对计数数据行卡方检验及Kaplan-meier法分析。结果:Lasp1蛋白在乳腺浸润性癌组织、乳腺导管内癌组织及正常组织中的阳性表达率分别为58.57%、28.57%、17.14%,3组之间表达差异有统计学意义(χ~2=28.26,P<0.01)。乳腺浸润性癌组织中Lasp1蛋白的表达与肿瘤直径、淋巴结转移及雌激素(ER)有关(P<0.05),但与年龄、临床分期、孕激素(PR)及表皮生长因子受体2(HER-2)无关(P>0.05)。Lasp1阳性表达的患者5年生存率低于Lasp1阴性表达的患者(χ~2=4.16,P<0.05)。结论:乳腺浸润性癌组织中Lasp1蛋白的过表达不仅有利于判断癌细胞的浸润转移,而且对预测患者5年生存率也有参考价值。
Objective: To investigate the expression of Lasp1 protein in breast invasive ductal carcinoma, intraductal carcinoma and normal tissues and its relationship with clinicopathological factors, and further analyze the influence of its expression on clinical prognosis. Methods: The expressions of Lasp1 protein in 70 cases of breast invasive carcinoma, 70 cases of intraductal carcinoma and 70 cases of normal tissue were detected by immunohistochemistry (En VisionTM). The count data were analyzed by Chi-square test and Kaplan- -meier analysis. Results: The positive rates of Lasp1 protein expression in breast invasive carcinoma, intraductal carcinoma and normal tissues were 58.57%, 28.57% and 17.14%, respectively. There was significant difference between the three groups (χ ~ 2 = 28.26, P <0.01). The expression of Lasp1 in invasive breast cancer was correlated with tumor diameter, lymph node metastasis and estrogen (P <0.05), but not with age, clinical stage, progesterone (PR) and epidermal growth factor receptor 2 -2) (P> 0.05). The 5-year survival rate of Lasp1 positive patients was lower than that of Lasp1 negative patients (χ ~ 2 = 4.16, P <0.05). Conclusion: The overexpression of Lasp1 protein in invasive breast cancer is not only helpful to judge the invasion and metastasis of cancer cells, but also has a reference value in predicting the 5-year survival rate of patients.