论文部分内容阅读
急性感染性多发性神根炎(GBS)是引起急性麻痹最常见的原因。目前已有三项试验分别认为血浆置换能加速患者运动能力的恢复,或静注免疫球蛋白可能有效,但都不能防止麻痹和减少严重残废的比例。类固醇对治疗与GBS病征相似的脱髓鞘疾病很有效,但对治疗GBS一直令人失望。在一项试验中,由于药量小,患者少(治疗组21例、对照组19例),发现强的松龙无效。本文作者采用一种多中心、随机双盲试验对大量GBS患者应用大剂量类固醇治疗以评价其疗效。
Acute infectious multiple root irritation (GBS) is the most common cause of acute paralysis. Three trials have now suggested that plasma exchange can accelerate the recovery of exercise capacity, or intravenous immunoglobulin may be effective, but they can not prevent paralysis and reduce the proportion of serious disability. Steroids are effective in treating demyelinating diseases similar in symptoms to GBS, but have been disappointing in the treatment of GBS. In one trial, prednisolone was found to be ineffective due to the small dose and few patients (21 in the treatment group and 19 in the control group). The authors used a multicentre, randomized, double-blind trial to assess the efficacy of high-dose steroid therapy in a large number of GBS patients.