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目的分析中国暗娼人群中DC-SIGN及DC-SIGNR基因多态性的分布,比较不同研究人群等位基因频率分布。方法PCR检测234例HIV阴性暗娼DC-SIGN及DC-SIGNR基因多态性。结果DC-SIGN基因型在234例中发现4例突变杂合子。DC-SIGNR等位基因频率以7次重复最为常见(65．2％),其次为5次重复(18．4％)和9次重复(1 1．9％),其基因频率分布与国外报道差异有统计学意义。结论DC-SIGN基因具有多态性,而DC-SIGNR基因多态性分布同国外报道比较存在差异。
Objective To analyze the distribution of DC-SIGN and DC-SIGNR gene polymorphism in Chinese FSW population and to compare the frequency distribution of alleles in different study populations. Methods The polymorphisms of DC-SIGN and DC-SIGNR in 234 HIV-negative female sex workers were detected by PCR. Results There were 4 mutant heterozygotes found in 234 cases of DC-SIGN genotypes. The frequency of DC-SIGNR allele was the most common among 7 repeats (65.2%), followed by 5 repeats (18.4%) and 9 repeats (1 1.9%). The gene frequency distribution of DC- The difference was statistically significant. Conclusion DC-SIGN gene polymorphism, and DC-SIGNR gene polymorphism distribution compared with foreign reports there are differences.