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对４４例原发性脑肿瘤的免疫组化研究发现，２９例（６７２％）的肿瘤细胞表达ＨＬＡ一Ｄｒ。ＨＬＡ一Ｄｒ阳性细胞含量和阳性率均与肿瘤的组织学类型有关，并随恶性程度增加而升高。肿瘤中浸润的单个核细胞（ＭＮＣ）主要是ＣＤ４５ＲＯ＋Ｔ细胞和单核巨噬细胞，前者主要包括ＣＤ４和ＣＤ８两个亚群。ＨＬＡ一Ｄｒ＋，组ＣＤ４５ＲＯ＋和ＣＤ８＋Ｔ细胞密度均低十ＨＬＡ一Ｄｒ一组。ＣＤ４亚群和单核巨噬细胞密度不受ＨＬＡ一Ｄｒ表达状况的影响。这说明脑肿瘤细胞表达的ＨＬＡ一Ｄｒ对参与局部抗肿瘤免疫的ＣＤ８亚群有选择性抑制作用。
Immunohistochemical study of 44 primary brain tumors found that 29 (672%) of the tumor cells expressed HLA-A HLA-Dr positive cell content and positive rate are related to the histological type of the tumor, and increased with the increase of the degree of malignancy. Infiltration of tumor mononuclear cells (MNC) is mainly CD45RO + T cells and mononuclear macrophages, the former mainly includes CD4 and CD8 two subgroups. HLA-Dr +, group CD45RO + and CD8 + T cell density were low ten HLA-Dr a group. The CD4 subpopulation and monocyte-macrophage density are not affected by HLA-DR expression status. This suggests that HLA-DR expressed by brain tumor cells selectively inhibits the CD8 subpopulation involved in local anti-tumor immunity.