论文部分内容阅读
胰岛移植能够纠正IDDM的高血糖并减少糖尿病相关并发症 ,临床广泛应用将造成尸源性胰腺供体严重不足 ,动物来源的胰岛将成为今后胰岛的主要供源。异种移植的最大障碍是移植排斥反应 ,目前控制异种胰岛移植的免疫抑制治疗无法在临床推广。啮齿动物实验研究证明异种胰岛移植不需要长期重度免疫抑制治疗就能获得生存 ;杂交系动物实验研究提示异种胰岛移植的临床应用是可行的。随着对大动物杂交种系间异种移植排斥机理和动物病原体传播能力的深入了解 ,异种胰岛移植将进入临床。
Islet transplantation can correct the high blood sugar of IDDM and reduce the complications associated with diabetes. The widely used clinical results will cause a serious shortage of the donor body of the pancreas, and the islet derived from the animal will become the main source of islets in the future. The biggest obstacle to xenotransplantation is graft rejection. The current immunosuppressive therapy for controlling islet xenotransplantation can not be clinically promoted. Rodent experimental studies have shown that xenotransplantation does not require long-term severe immunosuppressive therapy can survive; experimental studies of hybrid animals suggest that xenograft islet transplantation is feasible. With the understanding of the mechanism of xenotransplantation rejection and the ability of animal pathogens to disseminate in large crossbred hybrids, xenotransplantation will enter clinical practice.