缺血性卒中是目前危害人类的常见病之一,具有高发病率、高致残率、高死亡率等特点,严重威胁中老年人的身体健康。利用动物脑缺血及缺血再灌注模型来模拟人类脑血管疾病,制作最接近人类脑缺血的理想动物模型是人们普遍关注的课题。由于猪脑在解剖、生理及生化上与人类有极大的相似性,猪作为脑缺血模型动物的优越性已更多的被认识到。本文就猪的科研价值、不同的造模方法两个方面做如下综述。 Ischemic stroke is one of the most common diseases that endanger human beings. It has the characteristics of high morbidity, high morbidity and high mortality, and seriously threatens the health of the middle-aged and the elderly. The use of animal models of cerebral ischemia and ischemia-reperfusion to model human cerebrovascular disease and make the ideal animal model closest to human brain ischemia is a topic of general concern. Due to the great similarity of pig brain in anatomy, physiology and biochemistry with humans, the superiority of pigs as animal model of cerebral ischemia has been recognized more. This article summarizes the research value of pigs and different methods of making molds as follows.