软组织脊索瘤因为罕见和难与形态学相似的病变区分,至今未见系统研究报道。该研究使用brachyury蛋白抗体来确认诊断,分析11例的诊断经验。从该科室和会诊中检索编码为“脊索瘤”或“副脊索瘤”的病例(1989-2011),并进一步分析以排除骨或先前的中轴脊索瘤患者。27例患者中11例符合标准。患者男性8例,女性3例,年龄13~71岁,中位年龄44岁。肿瘤位于臀、腕部和下肢2例,脚趾、拇指、肩部和胸壁各1例。肿物直径0.5~10.9 cm(平均5.3 cm)。镜下肿瘤呈多小叶状 Soft tissue chordoma has not been reported systematically because of the rare and difficult morphological researches. The study used brachyury protein antibodies to confirm the diagnosis, analysis of 11 cases of diagnostic experience. Cases coded for “chordoma” or “paraneoplastic chordoma” were retrieved from this department and consultation (1989-2011) and further analyzed to exclude bone or previous patients with central chordoma. Eleven of the 27 patients met the criteria. There were 8 males and 3 females, aged 13-71 years, with a median age of 44 years. Tumor in the buttocks, wrists and lower extremities in 2 cases, toes, thumb, shoulder and chest wall in 1 case. The tumor diameter 0.5 ~ 10.9 cm (average 5.3 cm). Microscopic tumor was lobular