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目的 研究3种不同硬化剂的致硬化作用和其局部毒性.方法 36只新西兰兔的肝前性门脉高压食管静脉曲张模型,随机地分为5%鱼肝油酸钠组、1%乙氧硬化醇组和消痔灵注射液组,每组12只.经腹给兔行硬化剂注射治疗,分别于注射后72h、10天、20天将兔处死,肉眼观察管溃疡发生率并行组织学检查.结果5%鱼肝油酸钠组、1%乙氧硬化醇组的溃疡发生率分别为83.3%和58.3%,组织学上以“液化性坏死”为特征;消痔灵注射液组的溃疡发生率仅为16.7%,组织学上以“凝固性坏死”为特征.凝固性坏死可不经液化而为肉芽组织逐渐包裹、吸收,产生理想的纤维化.结论 消痔灵可能成为高效、低并发症的理想硬化剂.
Objective To study the sclerosis and local toxicity of three kinds of sclerosing agents.Methods The model of prehepatic portal hypertension in 36 New Zealand rabbits was randomly divided into 5% sodium morrhuate group, 1% Group and Xiaozhiling injection group, each group of 12. The abdomen to the rabbit sclerosing agent injection treatment, respectively, at 72h, 10d, 20d after injection, the rabbits were sacrificed, the incidence of tubular ulcers were observed with histological examination. Results The incidence rates of ulcer in 5% sodium morrhuate and 1% ethoxylated alcohol group were 83.3% and 58.3%, respectively. The histological features were “liquefaction necrosis”. The incidence of ulcer in Xiaozhiling injection group was only 16.7%, histological “coagulation necrosis” is characterized by coagulation necrosis without liquefaction for the granulation tissue gradually wrapped, absorbed, resulting in the ideal fibrosis.Conclusion Xiaozhi Ling may be the ideal of high efficiency and low complication hardener.