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目的：研究P53抑癌基因与子宫内膜腺癌的关系。方法：用免疫组化S-P法检测了正常子宫内膜、子宫内膜增殖症及子宫内膜腺癌组织中抑癌基因P53的表达情况。结果：突变型P53（mtP53）蛋白在子宫内膜组织中的阳性率为48．6％，而在正常子宫内膜及各种类型子宫内膜增殖症中均为阴性。说明P53的变异与子宫内膜腺癌的发生、发展有关。结论：突变型P53蛋白的出现与子宫内膜癌的恶性生物学行为有关。
Objective: To study the relationship between P53 tumor suppressor gene and endometrial adenocarcinoma. Methods: The expression of tumor suppressor gene P53 in normal endometrium, endometrial hyperplasia and endometrial adenocarcinoma was detected by immunohistochemical S-P method. Results: The positive rate of mtP53 protein in endometrial tissue was 48.6%, but negative in normal endometrium and various types of endometrial hyperplasia. P53 variation and endometrial adenocarcinoma of the occurrence and development. Conclusion: The appearance of mutant P53 protein is associated with the malignant biological behavior of endometrial cancer.