论文部分内容阅读
随着全球人口老龄化,阿尔茨海默病(Alzheimer’s disease,AD)发病率呈明显上升趋势。迄今为止,尚缺乏有效的AD治疗方法,早期诊断及防治是延缓AD进展的唯一有效方法。目前,AD的诊断仍主要依靠排除法和临床神经心理量表法,但其可重复性差且缺乏客观依据;因此,尚缺乏敏感且准确的AD早期诊断方法。随着影像学技术的发展,“医学影像学+”的学科交叉已成为新常态,由此产生的神经影像学技术可以清晰地显示脑内更细小的结构和病灶,这为AD的早期影像学诊断研究提供了基础。本文对磁共振成像(magnetic resonance imaging,MRI)应用于海马体积、内嗅区皮质厚度及杏仁核变化的检测以及双反转恢复(double inversion recovery,DIR)序列应用于AD诊断及弥散张量成像(diffusion tensor imaging,DTI)应用于海马相关脑白质损伤评估的最新研究进展进行综述。
With the global population aging, the incidence of Alzheimer’s disease (AD) shows a clear upward trend. So far, there is a lack of effective AD treatment, early diagnosis and prevention is the only effective way to delay the progress of AD. At present, the diagnosis of AD still rely mainly on the exclusion method and clinical neuropsychological scales, but its poor reproducibility and lack of objective evidence; therefore, the lack of sensitive and accurate early diagnosis of AD. With the development of imaging technology, the interdisciplinary “Medical Imaging +” has become a new normal, the resulting neuroimaging technology can clearly show the finer structures and lesions in the brain, which is the early stage of AD Imaging diagnosis provides the basis for the study. In this paper, the application of magnetic resonance imaging (MRI) in detection of hippocampal volume, cortical thickness in the entorhinal region and changes in the amygdala and double inversion recovery (DIR) sequences were applied to AD diagnosis and diffusion tensor imaging (diffusion tensor imaging, DTI) in the evaluation of hippocampal white matter damage.