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Four novel Schiff bases were synthesized by the condensation reaction of 2-hydroxyl-3-nitrobenzaldehyde with either benzothiazoles or benzimidazolamines.The compounds 1-4 were characterized by spectroscopic and analytical methods.The crystal structures of 6-methoxy-1,3-benzothiazol-2-amine and compound 2 are reported only.The 6-methoxy-1,3-benzothiazol-2-amine was found to crystallize in the orthorhombic crystal system in the space group Pbca,having eight molecules in the unit cell,while compound 2 was found to crystallize in the monoclinic crystal system in the space group P21/c.The biological activities of these compounds were investigated by evaluating their antibacterial,antifungal,antimalarial,anti-HIV and anti-trypanosomiasis activities.These compounds displayed very interesting antibacterial,antifungal,antimalarial,anti-trypanosomiasis,anti-HIV and low cytotoxicity activity against HeLa cells.