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有研究显示 ,体内的单核 巨噬细胞通过释放活性氧 (ｒｅ ａｃｔｉｖｅｏｘｙｇｅｎｓｐｅｃｉｅｓ,ＲＯＳ)可显著抑制ＮＫ细胞的抗肿瘤功能 ,而组胺则可有效逆转这种抑制。在上述工作的基础上 ,我们观察了在自体单核细胞存在的条件下 ,组胺对人外周血来源的淋巴因子激活的杀伤
Studies have shown that mononuclear macrophages in vivo can significantly inhibit the anti-tumor function of NK cells by releasing reactive oxygen species (ROS), while histamine can effectively reverse this inhibition. On the basis of the above work, we observed the activation of histamine on the activation of human peripheral blood-derived lymphokines in the presence of autologous mononuclear cells.